Yong men or women who have previously suffered from acne are likely to have longer telomeres in their white blood cells, meaning their cells could be better protected against aging, new research has found.
                     

Acne is a great problem for young men and woman. Scientifically it is called acne vulgaris. Acne is a long-term skin disease that occurs when hair follicles become clogged with dead skin cells and oil from the skin. Acne is characterized by areas of blackheads, whiteheads, pimples, and greasy skin, and may result in scarring. The resulting appearance can lead to anxiety,reduced self-esteem and, in extreme cases, depression or thoughts of suicide.

            

            

Genetics is thought to be the cause in 80% of cases. The role of diet and cigarette smoking is unclear and neither cleanliness nor sunlight appears to be involved. Acne primarily affects skin with a greater number of oil glands, including the face, upper part of the chest, and back. During puberty, in both sexes, acne is often brought on by an increase in androgen such as testosterone. Excessive growth of the bacteria Propionibacterium acnes, which is normally present on the skin, is often involved.


Now good news for acne suffers is that it might be a blessing for them. Scientists at King's College London have found that people who have previously suffered from acne are likely to have longer telomeres (the protective repeated nucleotide found at the end of chromosomes) in their white blood cells,meaning their cells could be better protected against aging.


The Telomeres are repetitive nucleotide sequences found at the end of chromosomes which protect them from deteriorating during the process of replication.Telomeres gradually break down and shrink as cells age, eventually leading to cell death which is a normal part of human growth and aging.


Previous studies have shown that white blood cell telomere length can be predictive of biological aging and is linked with telomere length in other cells in the body.


New study has published in the “Journal ofInvestigative Dermatology” measured the length of white blood cell telomeres in 1,205 twins from the Twins UK cohort. A quarter of the twins reported having experienced acne in their lifetime.


The statistical analyses which adjusted for age, relatedness, weight and height showed that telomere length in acne sufferers was significantly longer, meaning that white blood cells were more protected from the usual deterioration with age. One of the genes involved in telomere length was also associated with acne in a replication sample from the UK Acne Genetic study, also lead by King's scientists.

            

Telomere what we lose with age

            

The researchers have long observed that the skin of acne sufferers appears to age more slowly than the skin of those with no history of acne. Signs of aging such as wrinkles and skin thinning often appear much later in people who have experienced acne in their lifetime. It has been suggested that this is due to increased oil production but there are likely to be other factors involved.


Dermatologist team also examined gene expression in per-existing skin biopsies from the same twins to identify possible gene pathways linked to acne. One gene pathway (thep53 pathway), which regulates programmed cell death, was found to be less expressed in acne sufferers' skin. This requires further investigation to identify other genes involved in cell aging and how they differ in acne sufferers.


The lead scientist of the study, Dr Simone Ribero, a dermatologist from the Department of Twin Research and Genetic Epidemiology at King's, said: 'For many years dermatologists have identified that the skin of acne sufferers appears to age more slowly than in those who have not experienced any acne in their lifetime. Whilst this has been observed in clinical settings, the cause of this was previously unclear.


'Our findings suggest that the cause could be linked to the length of telomeres which appears to be different in acne sufferers and means their cells may be protected against aging. By looking at skin biopsies, we were able to begin to understand the gene expressions related to this. Further work is required to consider if certain gene pathways may provide a base for useful interventions.'


Dr Veronique Bataille, senior author of the paper and another dermatologist in the Department of Twin Research and Genetic Epidemiology said: 'Longer telomeres are likely to be one factor explaining the protection against premature skin aging in individuals who previously suffered from acne. Another important pathway, related to the p53 gene (a protector of the genome), is also relevant when we looked at gene expression in the skin of acne twins compared to twin controls.'


The study includes an entirely female twin cohort and it also did not identify a causal relationship; these are the main limitations of the research. The study also primarily used self-reporting of acne severity and treatment.

YOUR REACTION?


You may also like

Facebook Conversations



Disqus Conversations