We've known about some medical  conditions for centuries, even if we didn't have a name for them. Even you may be surprised to learn that they are just two of the thousands of very real and   rare  disorders that can have a great devastating impact on people's lives.

We've known about some medical conditions for centuries, even if we didn't have a name for them. Others have only recently come to our attention. Either way, the 36 medical conditions we're about to discuss are so peculiar that doctors, researchers and the people who live with them continue to work not only toward a cure, but toward a greater understanding of what the condition even is.

For people with rare or little-understood medical conditions, this frustrating scenario is generally how their doctor visits play out. And it can be very lonely there may only be a few dozen people in the entire world who have the same condition.

1. Alien Hand Syndrome

1. Alien Hand Syndrome Alien Hand

It sounds like something out of science fiction or a horror tale where a hand goes rogue and doesn’t do what you tell it to do.

The phrase, “the right hand doesn’t know what the left is doing” is actually literally true for some people. The condition involves a rogue hand that acts independently, grasping objects or moving in away contrary to what the individual wishes to do. 

The first case of alien hand syndrome (also known as anarchic hand) was documented in 1908 by a German euro-psychiatrist named Kurt Goldstein. He observed the patient to have no control over her left arm, as if someone else were controlling it. This neurological disorder occurs in people who have had the two hemispheres of their brains surgically separated, or from having a stroke, and even having Creutzfeldt–Jakob disease (human form of Mad Cow Disease). The hand basically becomes autonomous and the person believes it has a will of its own.

2. Progeria

2. Progeria A child facing Progeria

Progeria is also known as Hutchinson-Gilford progeria syndrome. While scientists,researchers and capitalists search for the secrets of longevity, the answer maybe found in the cure to that rare but heartbreaking disease which results in premature aging and death among children

Children born with progeria look like perfectly healthy babies in the first year of life. However, by the time they turn 2;most children with this unusual condition begin to show signs of advanced aging. Not only do the toddlers begin to look exactly like elderly adults, with thinning hair and wrinkled faces, they also begin to suffer from age-related diseases and infirmities; such as hardening of the arteries, loss of body fat,age spots on the skin, achy joints and bad hips. Kids with progeria share with seniors the same rates of cardiovascular disease and risk of stroke. Though they may live as long as 21, the average age of death is only 13.

Progeria occurs when a genetic defect occurs in a certain protein (Lamin A)that's responsible for the structural integrity of a cell's nucleus, first documented in 1886 in England. Progeria still has no cure.

3. Stone Man Syndrome

3. Stone Man Syndrome Stone Man Syndrome

Medical science called stone man syndrome as ossificans progressiva, or FOP. FOPis a progressive genetic disorder that turns soft tissues into bone over time.The ACVR1 gene found in bone, muscles, tendons, and ligaments regulates growth and development of those tissues, and is normally responsible for turning cartilage into bone as children develop. However, mutations of this gene can allow ossification to go unchecked throughout a sufferer's life, even turning skeletal muscle into bone and causing joints to fuse together.

This disorder occurs in about 1 in 2 million people, and there are currently no treatments or cures. Trauma exacerbates the condition, so attempts to remove bone surgically just results in the body producing even more bone in the area.

There’s no known cure for FOP today. However, in 1993, scientists discovered that squalamine, an extract from sharks may help in fighting FOP, but that has been put up for debate. The New York Times wrote an article about Harry Eastlack, perhaps the most well-known figure with FOP in modern day history.

4. Alice in Wonderland Syndrome

4. Alice in Wonderland Syndrome Alice in Wonderland Syndrome

Alice in Wonderland Syndrome is a rare psychological disorder where the sufferers experience size distortion, increased or decreased volume of sound, and exaggerated perception. Alice in Wonderland Syndrome is also known as Todd's syndrome, or lilliputian hallucinations. It happens in episodes and is very disorienting for the sufferer. AWIS happens when excess electrical activity causes abnormal blood flow into the area vision and the part of the brain that processes texture size and shape, which explains size distortion. It can also be the initial symptom of the Epstein–Barr viru.

It is documented that AIWS is frequent with childhood, but people grow out of it (although some have reported to have the disorder well into their 70s). It also occurs if muscimol, a psychoactive alkaloid, is ingested.

This syndrome was first discovered by Dr. John Todd in 1955, who was a British Consultant Psychiatrist at High Royds Hospital at Menston in West Yorkshire.

You may know the author Lewis Carroll. He had been a well known migraine sufferer with similar symptoms; Todd speculated that Carroll had used his own migraine experiences as a source of inspiration for his famous 1865 novel “Alice’s Adventures in Wonderland”.

5. Tree Man Syndrome

5. Tree Man Syndrome Tree Man Syndrome

Tree Man Syndrome or Lewandowsky and Lutz dysplasia, also known as epidermodysplasia verruciformis (EV), is an inherited disorder This is an extremely rare autosomal recessive hereditary skin disorder associated with a high risk of skin cancer, characterized by marked susceptibility to Human Papilloma Virus HPV (type 5, 8) infection, which in the normal population is asymptomatic, but in these patients gives rise to scaly maculopapular lesions of the hands and feet, which have been fancifully likened to tree bark.

It was first described by Felix Lewandowsky and Wilhelm Lutz in 1922, both dermatologists. More than 200 cases have been reported in the literature so far. Epidermodysplasia verruciformis is universal and affects persons of all races. No sexual preference is noted for epidermodysplasia verruciformis,although sex-linked and autosomal dominant inheritance has been described.

It has an onset of between the ages of 1–20, but can be seen in all age groups including children but the largest proportion is in patients aged 25-58 years(average 39 years).

In people with a genetic predisposition, there is a mutation of chromosome 17occurring within two genes EVER2 or EVER1, which leads to lowering of the immunological potential of the skin, such that it becomes easily penetrable by HPV virus up to the deep layers of the skin and there is emergence of clinical symptoms, whereas this same Virus (in favorable genetic conditions) is tolerated by the immune system.

6. Water Allergy

6. Water Allergy This woman have water allergy

Possibly the worst condition to exist, aquagenicurticaria, or “water allergy” is a painful skin reaction. The technical name being Aquagenic Urticaria, this disorder causes the individual to be allergic to water in any form, including tears.

As the majority of our body is made out of water,it seems odd that an allergy to it would even exist. Though it isn’t a true allergy because it doesn’t trigger a histamine response, there are some who develop itchy hives and welts even after mere minutes of water exposure. 

This condition is quite rare, and the cause isn’t well known. Some have speculated that the water itself isn’t the cause, but rather specific chemicals or impurities that are ubiquitous within water.However, even purified water can trigger a reaction among some. The most common treatment is topical application of capsaicin, which is used to relieve pain.

Recently, a British woman named Micaela Dutton explained to a local newspaper how she couldn’t even hold her boy because if he started sweating she would break out with an incredibly painful rash.


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